Manufacturing lab facilities are historically the most difficult building typology to decarbonize due to high process loads and complex structural requirements. Yet, for Genentech, decarbonizing this sector is a non-negotiable part of their goal to achieve true zero emissions by 2050. This session presents a case study of the Product Operations Single-Use Manufacturing Facility, a project that operationalizes these corporate ambitions by tracking LEED Platinum. Attendees will hear how the integrated project team—including the Owner, Architect, Energy Consultants, and GC—unified to meet Genentech’s ambitious corporate sustainability goals (50% footprint reduction by 2029). The discussion will dissect specific technical wins, including a BIM-driven analysis that reduced support steel by 87%, the use of prefabricated exterior wall panels, and the integration of BIPV (solar) façades. Critically, we will also highlight process innovation: referencing an LCA from a sister facility, we will demonstrate how the facility's Single-Use Technology (SUT) significantly reduces water and energy consumption compared to traditional stainless-steel manufacturing. Finally, we will share how technology—such as weekly 360° site scans—paired with early trade partner engagement drove a 93% construction waste diversion rate, proving that industrial projects can achieve zero-waste goals through team culture.